Major Holders

The names of our directors and executive officers, and certain additional information with respect to each of them, are set forth below.

Position Held* Position Held Percent of Outstanding Shares
Efficacy Capital Ltd. 4,292,136 28.28
New Enterprise Associates 1,000,000 6.59
Kleinheinz Capital Partners, Inc. 683,400 4.50
Vermillion Asset Management LLC 364,767 2.40
Visium Asset Management LLC 316,243 2.08
Dimensional Fund Advisors, Inc. 308,896 2.04
Wall Street Associates LLC 275,000 1.81
Barclays Global Investors NA 245,861 1.62
Vanguard Group, Inc. 134,962 0.89
Joseph S. Podolski 119,281 0.79
DWS Investment GmbH 106,400 0.70

* Data as reported by NASDAQ on June 3, 2009

2408 Timberloch Place, B-7
The Woodlands, Texas 77380
281-719-3400
281-719-3446 fax