| Position Held* |
Position Held |
Percent of Outstanding Shares |
| Efficacy Capital Ltd. |
2,580,013 |
20.2 |
| Visium Asset Management LLC |
1,180,687 |
9.24 |
| Promed Management, Inc. |
663,144 |
5.19 |
| Franklin Advisors, Inc. |
637,000 |
4.99 |
| RA Capital Management LLC |
579,806 |
4.54 |
| Seneca Capital Advisors LLC |
450,300 |
3.53 |
| Vermillion Asset Management LLC |
435,000 |
3.44 |
| Great Point Partners LLC |
280,940 |
2.2 |
| Wall Street Associates LLC |
275,000 |
2.15 |
| Dimensional Fund Advisors, Inc. |
263,243 |
2.06 |
| Barclays Global Investors NA (CA) |
217,697 |
1.7 |
| Joseph S. Podolski |
110,881 |
0.87 |
| DWS Investment GmbH |
106,400 |
0.83 |